Dr. Roee Gutman

• Energy homeostasis - Obesity
• Animal and Human Physiology
• Circadian Physiology
• Animal Behaviour

My field of interest is Integrative Physiology, i.e., the broader aspects of physiology, involving and integrating mechanisms and regulatory functions at all biological levels spanning from molecular, cellular, tissue, and organs. Specifically, I am interested in three main areas: the interplay between circadian physiology and metabolism, the examination of dietary supplements for attenuating metabolic syndrome, and an emerging topic of inquiry – insects as an alternative protein source.

We use animal models to assess:

1. The role of the endogenous circadian rhythm period-length, i.e., its deviation from the environmental light-dark cycle, in the susceptibility to obesity.
2. The efficacy of novel nutritional supplements for attenuating metabolic syndrome.
3. The efficacy of insect-based protein-rich meals for food and feed

2002-2007 and 2009-2011: Department of Life Sciences, Open University (Israel).
2010- present: Departments of Animal Science and Nutritional Sciences, Faculty of Sciences and Technology, Tel Hai College (Israel).

Courses taught in the Recent years at the Departments of Animal Science and Nutritional Sciences, Faculty of Sciences and Technology, Tel Hai College (Israel):

1. Grants Awarded

Scholarships, Awards and Prizes

1. Awards Received After Completion of Ph.D.

1. 2014           Tel-Hai College, Faculty of Life Sciences, Department of Animal Science, Department Award for Excellence in Teaching.
2. 2014           Physiological Society. Travel Award to attend the Physiological Society meeting, Newcastle, UK.
3. 2013           American Physiological Society. Travel Award to attend the XXXVII International Congress of Physiological Sciences, Birmingham, UK.

2. Awards Received Before Completion of Ph.D.

4. 2005-2008  Council for Higher Education (Israel), Lev-Zion Triennial Scholarship for Outstanding Ph.D. Students.
5. 2004           Minerva Foundation (Germany), Short-Term Research Grant.
6. 2003           UJA Federation of New York, Salim and Rachel Banin Scholarship for Excellence in Studies.
7. 2003           Tel Aviv University, Faculty of Life Sciences, Faculty Award for Excellence in Teaching and Studies.
8. 2002           Tel Aviv University, Department of Zoology, Adesman Scholarship for Outstanding M.Sc. students.
9. 1999           Mevo'ot Hermon Regional Council Scholarship for Students.
10. 1997         Edith and Henry Everett Scholarship for Outstanding Students.
11. 1996-1998            Israel Ministry of Education Scholarship for Students.

1. Articles in Refereed Journals

Published

1. Gutman R., J. S. Pendergast, W. Nakamura, and S. Kojima. Editorial: Circadian Desynchrony: Consequences, Mechanisms, and Open Issues. Frontiers in Physiology 14, 1177643. 2023. Available at:  https://doi.org/10.3389/fphys.2023.1177643.
2. Asher A.,  M Fialko, F. Fares, U. Moallem, S. Yaacoby, and R. Gutman. The effect of short-wavelength white LED illumination throughout the night on the milk fatty acid profile of high-yielding dairy cows. Biology. 2022, 11, 1799. Available at:  https://doi.org/10.3390/biology11121799
3. Opatovsky I., T. Vitenberg, A. Jonas-Levi, and R. Gutman. Does consumption of baker's yeast (Saccharomyces cerevisiae) by black soldier fly larvae (Hermetia illucens) affect their fatty acid composition?. Journal of Insect Science, 21 (3): 5, 1-5. 2021. Available at: https://doi.org/10.1093/jisesa/ieab031.
4. Steckler, R, S. Tamir, and R. Gutman. Mice held at an environmental photic cycle oscillating at their tau-like period length do not show the high-fat diet-induced obesity that develops under the 24-hour photic cycle. Chronobiology International 38 (4) 598-612. 2021. Available at: https://doi.org/10.1080/07420528.2020.1869029.
5. Binyamin D., Werbner N., Nuriel-Ohayon M., Uzan A., Mor H., Abbas A., Ziv O., Teperino R.,  Gutman R., and O. Koren. The aging mouse microbiome has obesogenic characteristics. Genome Medicine 12:87. 2020. Available at: https://doi.org/10.1186/s13073-020-00784-9
6. Gutman R., M. Rauch, A. Neuman, H. Khamaisi, A. Jonas-Levi, Y. Konovalovae and G. Rytwo. Sepiolite clay attenuates the development of hypercholesterolemia and obesity in mice fed a high-fat, high-cholesterol diet. Journal of Medicinal Food, 20 (3) 289-296. 2020. Available at: https://doi.org/10.1089/jmf.2019.0030.
7. Zecharia D., M. Rauch, A. Sharabi-Nov, S. Tamir, and R. Gutman. Postnatal administration of leptin antagonist mitigates susceptibility to obesity under high-fat diet in αMUPA male mice. American Journal of Physiology-Endocrinology and Metabolism. 2019. Available at:  https://doi.org/10.1152/ajpendo.00099.2019
8. Pinsky M., M. Rauch, A. Abbas, A. Sharabi-Nov, S. Tamir, and R. Gutman. Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge. PLoS ONE, 12(11): e0188658. 2017. Available at: https://doi.org/10.1371/journal.pone.0188658
9. Aharon Gutman, M. and R. Gutman. Will our voices be heard? An inside view of an environmental public struggle at the Israeli Northern Periphery. Israeli Sociology, 2: 196, 2017. (In Hebrew). Available at: https://www.israeli-sociology.sites.tau.ac.il/%D7%99%D7%97-2.
10. Garrido, M., Hochman Adler, V., Pnini, M., Abramsky, Z., Krasnov, B. R., Gutman, R., Kronfeld-Schor, N., and H. Hawlena. Time budget, oxygen consumption and body mass responses to parasites in juvenile and adult wild rodents. Parasites & Vectors, 9: 120, 2016. Available at: https://doi.org/10.1186/s13071-016-1407-7
11. Efrat, R., G. Shalev, R. Gutman, and N. Sapir. Does saline water consumption affect feeding and body condition of a staging, long distance migrating passerine. Journal of Avian Biology. 47: 378-385, 2016. Available at: https://doi.org/10.1111/jav.00770
12. Steckler, R, A. Shabtay-Yanai, M. Pinsky, M. Rauch, S. Tamir, and R. Gutman. Long-lived αMUPA mice show reduced sexual dimorphism in lifespan, and in energy and circadian homeostasis related parameters. The Journals of Gerontology The Journals of Gerontology Series: Biological Sciences, 71(4): 451-460, 2016. Available at: https://doi.org/10.1093/gerona/glv019
13. Ravussin, Y., R. Gutman, C.A. LeDuc, and R. L. Leibel. Estimating energy expenditure in mice using an energy balance Technique. International Journal of Obesity, 37: 399-403, 2013. Available at: https://doi.org/10.1038/ijo.2012.105
14. Barnea, M., L. Haviv, R. Gutman, N. Chapnik, Z. Madar, and O. Froy. Metformin affects circadian clock and metabolic rhythms in a tissue-specific manner. Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease, 1822 (11): 1796-1806, 2012. Available at: https://doi.org/10.1016/j.bbadis.2012.08.005
15. Gutman, R., M. Barnea, L. Haviv, N. Chapnik, and O. Froy. Peroxisome proliferator-activated receptor α (PPARα) activation advances locomotor activity and feeding daily rhythms in mice. International Journal of Obesity, 36: 1131-1134, 2012. Available at: https://doi.org/10.1038/ijo.2011.215
16. Ravussin, Y., O. Koren, A. Spor, C. A. LeDuc, R. Gutman, J. Stombaugh, R. Knight, R. Ley, and R. L. Leibel. Responses of gut microbiota to weight loss in lean and obese mice. Obesity, 20 (4): 738-747, 2012. Available at: https://doi.org/10.1038/oby.2011.111
17. Sherman, H., I. Fromin, R. Gutman, N. Chapnik, A. Lorentz, J. Meylan, J. le-Coutre, and O. Froy. Long-term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers in various mouse tissues. Journal of Cellular and Molecular Medicine, 15 (12): 2745-2759, 2011. Available at: https://doi.org/10.1111/j.1582-4934.2010.01160.x
18. Gutman, R., T. Dayan, I. Schubert, O. Levy, and N. Kronfeld-Schor. The effect of the lunar cycle on stress hormone levels and foraging ecology of nocturnally and diurnally active spiny mice. PLoS one, 6(8): e23446, 2011. Available at: https://doi.org/10.1371/journal.pone.0023446. Part of this work was first published as a conference proceeding, see D.10.
19. Gutman, R., Y. Genzer, N. Chapnik, R. Miskin, and O. Froy. Long-lived αMUPA mice exhibit 24 h locomotor activity circadian rhythms. Experimental Gerontology. 46: 606-609, 2011. Available at: https://doi.org/10.1016/j.exger.2011.02.015. This work was first published as a conference proceeding, see D7.
20. Sherman, H., R. Gutman, N. Chapnik, J. Meylan, J. le-Coutre, and O. Froy. Caffeine alters circadian rhythms and expression of disease and metabolic markers. International Journal of Biochemistry & Cell Biology, 43: 829-838, 2011. Available at: https://doi.org/10.1016/j.biocel.2011.02.008
21. Sherman, H., R. Gutman, N. Chapnik, A. Lorentz, J. Meylan, J. le-Coutre, and O. Froy. All-trans retinoic acid modifies the expression of clock and disease marker genes. Journal of Nutritional Biochemistry, 23: 209-217, 2012. Available at: https://doi.org/10.1016/j.jnutbio.2010.11.017
22. Ravussin, Y.*, R.* Gutman, S. Diano, M. Shanabrough, E. Borok, B. Sarman, A. Lehmann, C.A. LeDuc, M. Rosenbaum, T.L. Horvath, and R. L. Leibel. Effects of Chronic Weight Perturbation on Energy Homeostasis and Brain Structure in Mice. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 300 (6): R1352-62, 2011. * The authors contributed equally to this work. Available at: https://doi.org/10.1152/ajpregu.00429.2010
23. Froy, O., H. Sherman, G., Bhargava, N. Chapnik, R. Cohen, R. Gutman, N. Kronfeld-Schor, and R. Miskin. Spontaneous caloric restriction associated with increased leptin levels in obesity-resistant alpha MUPA mice. International Journal of Obesity, 35: 226-235, 2011. Available at: https://doi.org/10.1038/ijo.2010.125
24. Stratigopoulos G., C. A. LeDuc, N. Matsuoka, R. Gutman, R. Rausch, S. A. Robertson, M. G. Myers Jr, W. K. Chung, SC. Chua Jr, and R. L. Leibel. Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity, 17(1):126-35, 2009. Available at: https://doi.org/10.1038/oby.2008.489
25. Gutman, R., R. Keren, I. Choshniak, and N. Kronfeld-Schor. Effect of food availability and leptin on the physiology and hypothalamic gene expression in a desert rodent that does not hoard food, the golden spiny mouse. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 295: R2015-R2023, 2008. Available at: https://doi.org/10.1152/ajpregu.00105.2008
26. Gutman, R., D. Yosha, I. Choshniak, and N. Kronfeld-Schor. Two strategies for coping with food shortage in desert golden spiny mice. Physiology & Behavior, 90(1): 95-102, 2007. Available at: https://doi.org/10.1016/j.physbeh.2006.08.033
27. Gutman, R., I. Choshniak, and N. Kronfeld-Schor. Defending body mass during food restriction in Acomys russatus – a desert rodent that does not store food. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 290 (4): R881-R891, 2006. Available at: https://doi.org/10.1152/ajpregu.00156.2005.
28. Gutman, R., and T. Dayan. Temporal partitioning: An experiment with two species of spiny mouse. Ecology, 86(1): 164-173, 2005. Available at: https://doi.org/10.1890/03-0369.
29. Gutman, M., A. Perevolotsky, R. Yonatan, and R. Gutman. Grazing as a management tool for prevention of fire in open areas: Ramat Hanadiv Park (1990-1999). Ecology and Environment 6: 239-248, 2001.

B. Articles or Chapters in Scientific Books (which are not Conference Proceedings)

Published

1. Gutman, M., R. Yonatan, and R. Gutman. Cattle grazing for wildfire prevention at Ramat Hanadiv (1990-2005). In: Perevolotsky, A. (ed.). Conserving and managing Mediterranean ecosystem: The Ramat Hanadiv case study and beyond. Ramat Hanadiv. Zichron Ya’akov. 2013.
2. Dayan, T., R. Gutman and Y. Mandelik. Biological diversity indicators. In: Feitelson E. (ed.). Sustainable development indicators in Israel. Jerusalem Institute for Israel Studies. 2004.

C. Articles in Conference Proceedings

Published Abstracts

1. Asher, A., R. Gutman, U. Moallem, F. Fares, M. Cohen-Zinder, and A. Shabtay. O18 The dark side of the light: the effect of led illumination on feed efficiency, production and welfare of livestock. Animal-Science Proceedings, 14(4), 558-559, 2023.
2. Rytwo, G., A. Sitruk, R. Lavi, H. Khamaisi, and Gutman, R. De-emulsification of oil emulsions by clays and nanocomposites, EU COST-HINT Scientific Workshop and Review Meeting, Milan, 2015. Available at: http://dx.doi.org/10.13140/RG.2.2.15149.92645.
3. Rytwo, G., A. Sitruk, R. Lavi, H. Khamaisi, and Gutman, R. De-emulsification of oil emulsions by clays and nanocomposites, 5th Galilee Biomedical Conference, Tel Hai, Israel, 2015.
4. Gutman, R., M. Rauch, A. Neuman, H. Khamaisi, A. Jonas-Levi, and G. Rytwo. Sepiolite clay attenuates the development of obesity and prevents hypercholesterolemia and hyperlipidemia in mice fed a high-fat high-cholesterol diet. 5th Galilee Biomedical Conference, Tel Hai, Israel, 2015.
5. Steckler, R, H. Choen, S. Tamir, and R. Gutman. Holding mice at an environmental photic cycle that matches their endogenous circadian rhythm period length prevents diet-induced obesity. Obesity. (New Castel, United Kingdom). Proceedings of the Physiological Society. 32. PC20. 2014. Available at: https://www.physoc.org/abstracts/holding-mice-at-an-environmental-photic-cycle-that-matches-their-endogenous-circadian-rhythm-period-length-prevents-diet-induced-obesity/.
6. Rytwo, G., R. Lavi, Y. Konovalova1, and R. Gutman. Adsorption of olive oil on clay minerals and nanocomposites. Proceedings of 51st Annual Meeting of the Clay Minerals Society (College Station, Texas, USA), 2014. Available at: http://dx.doi.org/10.13140/RG.2.1.4926.0240
7. Gutman, R. and O. Froy. Long-lived and obesity resistant mice exhibit 24 h locomotor circadian rhythms at young and old age. Proceedings of The Physiological Society. 37th Congress of IUPS (Birmingham, UK), 2013. Available at: https://www.physoc.org/abstracts/long-lived-and-obesity-resistant-mice-exhibit-24-h-locomotor-circadian-rhythms-at-young-and-old-age/.
8. Gutman, R., I. Choshniak, and N. Kronfeld–Schor. Hormonal, behavioral and biochemical mechanisms in adaptation of the golden spiny mouse (Acomys russatus) to variations in food availability. Israel Journal of Zoology, 50(1): 109, 2004. This work was also published in a refereed journal; see B.27.
9. Gutman, R., I. Sinai, E. Sadot, and Y. Shkedy. Road kills and under-road pass utilization by animals – a preliminary survey. Israel Journal of Zoology, 49(2): 79-80, 2003.
10. Gutman, R., and T. Dayan. Moon-struck spiny mice: the influence of moon cycle on diurnal and nocturnal foraging behavior. Israel Journal of Zoology, 48(2): 170, 2002.
11. Gutman, R., and T. Dayan. Foraging behaviour of Acomys russatus in absence of its competitor Acomys cahirinus: The role of exploitation competition and interference competition in competitive exclusion. Israel Journal of Zoology, 47:183, 2001. This work was also published in a refereed journal; see B.28.
12. Gutman, R., M. E. Jones, and T. Dayan. Influence of habitat structure and food quality on foraging behavior of spiny mice (genus Acomys). Israel Journal of Zoology, 46(2): 161, 2000.

D. Other Publications

Patents

1. Gutman, R. and G. Rytwo. (2017) US provisional patent application number No 62/588,664 "Acicular clays and biocomposites based thereon for use in the treatment of metabolic syndrome and related disorders" filed November 20, 2017.

1. Participation in Scholarly Conferences

1. Active Participation

Conferences in Israel

Conferences held abroad

2. Organization of Conferences or Sessions (**= since tenure)

2. Invited Lectures\ Colloquium Talks (**= since tenure)

Laboratory of Integrative Physiology (LIP), The Department of Nutrition and Natural Products,

MIGAL – Galilee Research Institute.

P.O.B. 831, Kiryat Shmona, 11016, Israel.

Tel: 972-4-6953569 (office); 972-52-8422601 (mobile); Fax: 972-4-6944980.

E-mail: [email protected]; [email protected]; [email protected]

LinkedIn: https://www.linkedin.com/in/roee-gutman-0889208/

ORCID no: https://orcid.org/0000-0002-3282-6558

Website: https://www.migal.org.il/en/integrative-physiology

ResearchGate: https://www.researchgate.net/profile/Roee_Gutman