Prof. Dani Bercovich

Prof. Dani Bercovich
דני ברקוביץ
Accordion Title Areas of Interest

Areas of Interest

I started my academic education in 1988, studying for a bachelor's degree in animal science at the Faculty of Agriculture of the Hebrew University of Jerusalem. After graduating magna cum laude in 1991, I continued on to a master's degree in food consumption control, also at the Faculty of Agriculture, under the supervision of Professor Nahum Snapir, the dean of the faculty at the time.

After completing my master's degree in 1993, I was accepted for doctoral research by the Department of Genetics at the Hebrew University of Jerusalem, in 1994. My research was conducted under the supervision of Prof. Yossi Greenbaum, then head of the department and with the help of Dr. Yoram Plotzky, head of the genetics laboratory at MIGAL - Galil Research Center. The study concentrated on finding linkages between developmental genes of the HOMO-Box family (HOX) and quantitative characteristics in animals, using the number of hen's eggs per year of laying as a model. As part of the research, I developed molecular methods for working with DNA directly from fowl blood and methods for identifying restriction enzymes in genomic areas of the HOMO-Box genes for possible association.

After completing my doctorate in 1998, I remained at the genetics lab at MIGAL as a post-doctoral researcher, focusing my work mainly on development of a method to isolate embryonic cells from the blood of pregnant women.

In 1999, I received a full scholarship from the Baylor College of Medicine in Houston, Texas, to work under the supervision of Professor Art Beaudet (MD), then head of the Department of Genetics, a key participant in the Human Genome Project at the time. During my post-doctoral period at Baylor, I specialized in two areas. One was the isolation (cloning) of nicotinic receptor (CHRN) genes and the preparation of knockout mice, which produced several coauthored articles (Lev-Lehman et al., 2001; Arredondo et al., 2002; Arredondo et al., 2003(2); Nguyen et al., 2004; Liang et al., 2005). Later in my postdoctoral fellowship, I shifted my focus to a new technique for scanning mutations, known as DNA chromatography (denaturing high-performance liquid chromatography (DHPLC)).

The development of optimal use of this method resulted in numerous collaborations and publication of articles that identified mutations in patients of various types, including the UBR3A gene, which is associated with Angelman syndrome (Bercovich & Beaudet, 2003), and the LDLR gene, which is known to be associated with family Hypercholesteremia (Bodamer et al., 2002). In addition,, the method was adapted for the first time for haploid DNA from bacteria associated with meningitis (Shlush… & Bercovich, 2002). This work was done in collaboration with Prof. Beaudet and Prof. Lupski (who replaced Professor Beaudet as head of the genetics department at Baylor).

At the end of 2001, I returned to Israel, where I became the head of the molecular genetic laboratory at the MIGAL Research Institute and was also accepted to work at the genetic research laboratory of Ichilov Hospital's Genetic Institute, in cooperation with Prof. Avi Or-Ortanger and Prof. Yuval Yaron.

Based on my special ability to scan genomic components for new mutations, I have collaborated with a large number of researchers. I have been awarded a number of grants, for which all entire research activity was conducted in my laboratory under my guidance. Some of these include, for example, research carried out in collaboration with Prof. Eran Littersdorff, director of the Department of Internal Medicine at Hadassah Ein Karem, and with Prof. Gidi Rehavi and Prof. Shai Yizraeli of the Oncology Institute at Tel Hashomer.

These research collaborations yielded a large number of publications, such as an article on the RNASEL gene in prostate cancer of Ashkenazi origin-patients, together with Prof. Avi Or (Rennert et al., 2002); on mutations in the MECP2 gene in Rett patients with Prof. Yuval Yaron (Yaron et al., 2002) and on familial dysautonomia (FD) (Lehavi et al., 2003); on mutations in the GATA1 gene in children with Down syndrome who also have leukemia with Prof. Shai Izraeli (Rainis et al., 2003); a study that led to the collaboration of about 8 years, including the training of a graduate student together (see below); with Prof. Tamar Degani of Beilinson Hospital, on Fanconi anemia in the Arab population in Israel (Dgany et al., 2004); on mutations in the ARTS gene related to blood cancer with Prof. Sarit Larish from Rambam Hospital (Elhasid et al., 2004); on mutations in the SNAP29 gene associated with skin diseases with Prof. Eli Shpecher from Ichilov Hospital, (Sprecher et al., 2005); on mutations in the ENPP1 in collaboration with Prof. Ruti Parvary of Ben Gurion University (Levy-Litan et al, 2010); on the identification of mutations in congenital glaucoma patients for prenatal diagnosis in those families in collaboration with Prof. Orna Gayer, director of the Department of Ophthalmology at Carmel Hospital (Geyer et al., 2011) and many more articles.

The collaboration with Prof. Eran Littersdorff of Hadassah Ein Karem led to my entry into the field of personalized medicine (pharmacogenetics) and to publication in the high-impact journal, Atherosclerosis, on the first-ever determination of the genetic haplotypes in the CETP and MDR1 genes, which predict the possible response to the treatment of statins.

At the same time, I also collaborated with genetics researchers of various types of cancer, such as with Prof. Tamar Peretz, director of the Sharett Institute at Hadassah Ein Karem Hospital, on breast, ovarian, and colorectal cancers (Kadouri et al., 2007; Goldberg et al., 2007; Goldberg et al., 2008; Toledano et al., 2008; Goldberg et al., 2010; Sagi et al., 2011), as well as with the group of onco-gastrology at Ichilov Hospital with the late Prof. Paul Rosen and Dr. Guy Rosner (Elizabeth Half et al., 2009; Rosner et al., 2010; Rozner et al., 2015).

A large number of master's degree students have conducted research in my lab. I will mention two of these projects: Arava Aderet's research, which was carried out in collaboration with Prof. Yair Anixter from the Tel Hashomer Institute, on the genetic mutations of PKU patients in Israel (Bercovich et al., 2008 ]AHG[; Bercovich et al., 2008 [JHG]), and the work of Tal Yardeni, also in collaboration with Prof. Anixter and Prof. Shapiro of Beilinson Hospital, on mapping the mutations of children suffering from PFIC liver diseases (Shapiro…& Bercovich 2010).

As mentioned above, I have been collaborating for nearly 8 years with the group led by Prof. Shai Izraeli at the Tel Hashomer Cancer Institute. The study is focused on finding genetic mutations for blood cancer (mostly, but not exclusively ALL) and investigating the biological effect of these changes, to try to understand the treatment options for these patients. The study began with a joint grant from the Ministry of Trade and Industry, which enabled the acquisition by our lab of several dozen human cell lines, representing different types of blood cancer, and a search for mutations in these lines on specific pathways growth that might have malfunctioned and could lead to improper proliferation and differentiation of cells in the bone marrow. This study, among other things, directed us to the gene of the tyrosine kinase enzyme called JAK2. The research on this gene in ALL patients (in collaboration with European researchers) and the biological understanding of the effect of mutations (gain of function) was published in the high-impact journal Lancet (Bercovich et al., 2008). Follow-up studies from this project, including the work of our doctoral student Chen Shohat, who did most of her work in my lab, led to several publications in prestigious journals (Hertzberg et al., 2010; Shochat et al., 2011 [J Exp Med]; Tal et al., 2014; Shochat et al., 2014).

In 2009, I was one of the founders, in collaboration with Dr. Yoram Plotzky, of the GGA Genetic center in Katzrin. At this institute, only new molecular technologies were introduced, which were not available in Israel at the time (so that most complex genetic tests were sent abroad).
Within a few years, a large number of genetic tests were developed using genetic chip techniques (like Fluidigm), which completely changed the way of genetic testing in Israel. The development of these tests led to reduction in the price of tests in Israel by hundreds of percent, changing the entire field. This included, among other things, the development of comprehensive tests such as identification of breast/ovarian cancer sensibility, by testing 15 common mutations instead of only 3 (of Ashkenazis only); testing 25 common mutations in colon cancer (not previously available); testing 100 recessive mutations (carrier screening ) instead of just a few dozen according to ethnic origin; a test of 8 most common mutations associated with coagulation malfunction (women who take birth control pills, or people who fly frequently) and other tests. In 2014, the lab adopted the new NGS technology and we developed a number of tests based on this capability, such as the complete sequencing of about 300 genes related to recessive diseases and a panel of about 1200 point mutations for expanded carrier screening. In addition, it enables researchers from Israel to carry out their genomic research in Israel. Examples of this kind of collaboration can be seen in the identification of new genes involved in sexual immaturity, together with Prof. Yardena Tenenbaum of Haemek Hospital, which resulted in finding a new gene (MCM8) involved in this syndrome (Tenenbaum-Rakover et al., 2015). The ability to perform full exom sequencing also helped us in the identification of new mutations in the IGSF1 gene (Tenenbaum- Rakover…& Bercovich 2016). This collaboration is continuing in raising research funds and screening for mutations in these syndromes.

Under my initiative and guidance (together with the school staff), a group of students from the biology program at Danziger High School in Kiryat Shmona performed research in my lab. The students were awarded a gold medal at the IGEM competition (November 2016), which took place at Harvard Medical School in Boston, for the development of a DNA gene chip to identify a genetic profile for sensitivity to different tastes and the possibility of enzymatic change of this sensitivity using the CRISPR technique.

My expertise in the implementation of CGH genetic array (quantitative analysis of hereditary material) led to a breakthrough in the ability to diagnose individual sperm cells for in vitro fertilization. The aim of the study, which is being conducted in collaboration with Dr. Arie Berkovitz (no family connection, at least as far as we know) of Meir Hospital and Tel Aviv University) is to develop the possibility of using genetic chips on a single sperm cell, without the need for diploid DNA mixing (which had not been done anywhere in the world before that), to detect the genetic stability of those cells. This would enable use of only those sperm cells with the right morphology for fertilization, instead of the current method of choosing, where the correlation between sperm cell morphology and fertilization success is only 20%. This work was published in the high-impact journal, Human Reproduction and a number of Provisional Patents have been registered to allow us to raise more funds for continued developing of this capability.

In addition to research in the field of human genetics, I have also conducted several genetic studies of plants and animals. In the field of animal genetics, I would like to mention three examples of studies in this field. One is a collaboration with Prof. Gadi Degani of MIGAL Research Institute, to identify genes that control koi fish colors (Bercovich et al, 2012). The other is a study of genomics of domestication, in collaboration with Dr. Yaron Dekel from the Shamir Research Institute, in which a transposome element was found that penetrated or did not enter the control area of the TP53 (promoter region), which probably determines the duration of milk production in bovines (Dekel … & Bercovich, 2015 [BMC Genomics]). This research is still continuing; under our supervision, masters students are studying this field (see below). In addition, together with Dr. Dekel, a method was developed for performing genetic testing in the area of personalized medicine for dogs in Israel. In this test, the dogs are regularly checked for mutations in the MDR1 gene. The mutation prevents the dog from being vaccinated against the parks worm. To date, thousands of dogs in Israel have been tested (Dekel…. & Bercovich 2017).

Accordion Title Research

Research

Plans for Continuing Research and Academic Activity in the Coming Years
irst of all, I plant to continue developing new genetic tests, for example:
  • In the field of personalized medicine field - matching about 100 different SNPs to the way people respond to 500 generic drugs.
  • In the field of neuro-genomics – development of a test to identify changes in the human genome that will predict how people react to different components in food and their responses to different diets and sports activities.
  • Development of tests to detect known mutations on circulating fetus DNA from maternal blood.

In addition, in the coming years I will participate in three additional areas of research:
  • Some of my research will focus on the use of NGS technology to locate genomic components associated with late-onset sexual syndromes, in cooperation with Prof. Yardena Tenenbaum of Haemek Hospital. I will also focus on finding new genes associated with congenital glaucoma. At present, we can find mutations in known genes (such as CYP1B1) in only 70% - 80% of the patients, and in particular, we do not find mutations in the Ashkenazi population. This research is a continuation of collaboration with Prof. Orna Gayer of Carmel Hospital.
  • In the field of genomics research behind domestication, several studies will be carried out, including the function analysis of gene promoters (other than the TP53 gene, the transposome element of which is already known in the promoter and the function of which has been tested at the cellular level – the publication will be submitted soon). This kind of research also includes bioinformatics and cellular level analyses; it is being done in collaboration with Dr. Yaron Dekel of the Shamir Research Institute and the Archaeo-zoology research group of Haifa University.
  • Another research direction in which I plan to be very active, is the continued effort to characterize the genetic stability of individual sperm cells using the CGH genetic chips. We already know, based on research with Dr. Arie Berkovitz, that the appearance of vacuoles in sperm cells does not necessarily predict whether the sperm cell is normal or not, and their location is very important (see our paper in Human Reproduction). However, the sperm cell has a large number of occurrences (shapes) and all of them should be checked and compared with the genetic stability (chromosomal stability), in order to establish which is the most appropriate cell. These research activities will be conducted in my laboratory over the next few years.

 

Accordion Title Teaching

Teaching

Prof' Bercovich was the head of the MSc in Bio-technology program and Is responsible for the field of genetics and lecture in these academic courses: Genetics & Principle of Genetics, Molecular Genetics, Animal breeding, Bio-informatics for Undergraduates and Gene therapy, Bio-technology in medicine, Human Genetics and advance course in Bioinformatics for MSc students.  

Accordion Title Awards

Awards

Under my initiative and guidance (together with the school staff), a group of students from the biology program at Danziger High School in Kiryat Shmona performed research in my lab. The students were awarded a gold medal at the IGEM competition (November 2016), which took place at Harvard Medical School in Boston, for the development of a DNA gene chip to identify a genetic profile for sensitivity to different tastes and the possibility of enzymatic change of this sensitivity using the CRISPR technique.

Accordion Title Publications

Publications

Articles in refereed journals

(h-index = 26; (https://www.scopus.com/authid/detail.uri?authorId=6701761482) (IF = 5-years – Impact Factor)

Published and accepted for publication

Khatib, H, Berkovitz, D., Ratz, T, Plotsky, Y, Fainsod, A and Gruenbaum, Y. (1995). Mapping the CdxA gene to a new linkage group in chickens. Animal Genetics, 26, 211. ((1-page publication)

Pitcovski, J., Ohana, N., Amzaleg, S., Krispel, D., Bercovich, D., & Pinchasov, Y. (1997). Identification of a starting point of breast skin tears during chicken plucking. Poultry Science7, 405-409. IF:2.089 (6/58 – Agriculture, Dairy & Animal Science; Q1) Cited 1 time (Cite Score = 2.04 (2016))

Pitcovski, J., Bercovich, D., Azar, M., Gotfrid, Y., & Bendhaim, U. (1998). Comparison of raising budgerigars by both parents or by the male only. Journal of Avian Medicine & Surgery, 12(4), 263-267. IF:0.68 (97/136 – Veterinary Sciences; Q3) Cited 0 time (Cite Score = 0.53 (2016))

Bercovich, D., Plotsky, Y., & Gruenbaum, Y. (1999). Improved protocol for using avian red blood cells as substrates for the polymerase chain reaction. Biotechniques26(6),1080-1082. IF:2.713 (50/77 – Biochemistry Research Methods; Q3) Cited 1 time (Cite Score = 1.16 (2016))

Bercovich, D., Regev, R., Ratz, T., Gruenbaum, Y., Luder, A., & Plotsky, Y. (1999). The quantitative ratio of primer pairs and annealing temperature affect PCR products in multi-band amplification. Biotechniques27(4), 762-764, 766-768, 770. IF:2.713 (50/77 – Biochemistry Research Methods; Q3) Cited 8 times (Cite Score = 1.16 (2016))

Bercovich, D., Lev-Lehman, E., & Beaudet, A. L. (2000). Denaturing High Performance Liquid Chromatography (DHPLC) used in the detection of mutations and polymorphism in the UBE3A gene. American Journal of Human Genetics, 67(4), 1339 Suppl. 2 Oct. 2000. (1-page publication)

Lev-Lehman, E., Bercovich, D., Xu, W., & Beaudet A. L. (2000). Megacystic, Microcolon, Hypoperistalsis (MIMIHS) and pseudo-obstruction syndrome: Searching for the human genes. American Journal of Human Genetics, 67(4), 2192 Suppl. 2 Oct. 2000. (1-page publication)

Lev-Lehman, E., BercovichD., Xu, W., & Beaudet, A. L. (2001). Characterization of the human 4 nicotinic acetylcholine receptor gene (CHRNB4) and polymorphisms in CHRNA3 and CHRNB4. Journal of Human Genetics, 46, 362-366. IF: 2.358; 85/166 - Genetics & Heredity; Q3) Cited 22 times (Cite Score = 2.18 (2016))

Kashork, C. D., Stockton, D. W., Sahoo, T., Bercovich, D., Shaffer, L. G., & Beaudet, A. L. (2002). Genetics of autism: Identification of chromosomal abnormalities and susceptibility loci on chromosome 15q in autism families. American Journal of Human Genetics, 71(4), 1793 Suppl. S Oct., 2002. (1-page publication)

Shlush, L. I., Behar, D. M., Zelazny, A., Keller, N., Lupski, J. R., Beaudet, A. L., & Bercovich, D. (2002). Molecular epidemiological analysis of the changing nature of a Meningococcal outbreak following a vaccination campaignJournal of Clinical Microbiology, 40(10), 3565-3571. IF: 3.85 (33/124 – Microbiology; Q2) Cited 28 times (Cite Score = 3.57 (2016))

Rennert, H., Bercovich, D., Hubert, A., Abeliovich, D., Rozovsky, U., Bar-Shira, A., Soloviov, S., Schreiber, L., Matzkin, H., Rennert, G., Kadouri, L., Peretz, T., Yaron, Y., & Orr-Urtreger, A(2002). A novel founder mutation in the RNASEL Gene, 471delAAAG, is associated with prostate cancer in Ashkenazi Jews. American Journal of Human Genetics, 71(4), 981-984. IF: 10.362 (8/166 – Genetics & Heredity; Q1) Cited 95 times (Cite Score = 8.43 (2016))

Bodamer, A. O., Bercovich, D., Schlabach, M., Ballantyne, C., Zoch, D., & Beaudet, A. L. (2002). Use of denaturing HPLC to provide efficient detection of mutations causing familial hypercholesterolemia. Clinical Chemistry48(11), 1913-1918. IF: 7.965 (1/30 – Medical Laboratory Technology; Q1) Cited 25 times (Cite Score = 3.54 (2016))

Gavert, N., Naiman, T., Bercovich, D., Rozen, P., Shomrat, R., Legum, C., & Orr-Urtreger, A. (2002). Molecular analysis of the APC gene in 71 Israeli families: 17 novel mutations. Human Mutation19(6), 64-66. IF: 4.809 (29/166 – Genetics & Heredity; Q1) Cited 31 times (Cite Score = 4.51 (2016))

Yaron, Y., Ben Zeev, B., Shomrat, R., Bercovich, D., Naiman, T., & Orr-Urtreger, A. (2002). MECP2 Mutations in Israel: Implications for molecular analysis, genetic counseling and prenatal diagnosis in Rett syndrome. Human Mutation, 20(4), 323-324. IF: 4.809 (29/166 – Genetics & Heredity; Q1) Cited 24 times (Cite Score = 4.51 (2016))

Arredondo, J., Nguyen, V., Chernyavsky, A. I., Bercovich, D., Orr-Urtreger, A., Kummer, W., Lips, K., Vetter, D. E., Beaudet, A. L., & Grando, S. A. (2002). Central role of alpha-7 nicotinic receptor in differentiation of the stratified squamous epithelium. Journal of Cell Biology159(2), 325-336. IF: 9.306 (27/189 – Cell Biology; Q1) Cited 106 times (Cite Score = 6.83 (2016))

Bercovich, D., & Beaudet, A. L. (2003). UBE3A mutation analysis by DHPLC. Genetics Testing7(3) 189-194. IF: 1.488 (114/156 – Genetics & Heredity; Q3) Cited 21 times (Cite Score = 1.34 (2016))

Rainis, L., Bercovich, D., Strehl, S., Teigler-Schlegel, A., Stark, B., Trka, J., Amariglio, N., Biondi, A., Muler, I., Rechavi, G., Kempski, H., Haas, O. A., & Izraeli, S. (2003). Mutations in exon 2 of GATA1 are early events inmegakaryocytic malignancies associated with trisomy 21. Blood102(3), 981-986. IF: 10.891 (2/70 – Hematology; Q1) Cited 190 times) (Cite Score = 6.93 (2016))

Lehavi, O., Aizenstein, O., Bercovich, D., Pavzner, D., Shomrat, R., Orr-Urtreger, A., & Yaron, Y. (2003). Screening for familial dysautonomia in Israel: evidence for higher carrier rate among Polish Ashkenazi Jews. Genetics Testing7(2), 139-142. IF: 1.488 (114/156 – Genetics & Heredity; Q3) Cited 29 times (Cite Score = 1.34 (2016))

Arredondo, J., Hall, L. L., Ndoye, A., Nguyen, V. T., Chernyavsky, A. I., Bercovich, D., Orr-Urtreger, A., Beaudet, A. L., & Grando, S. A. (2003). Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine. Laboratory Investigation, 83(2), 207-225. IF: 4.401 (16/128 – Medicine, Research & Experimental; Q1) Cited 64 times (Cite Score = 4.57 (2016))

Arredondo, J., Nguyen, V. T., Chernyavsky, A. I., Bercovich, D., Orr-Urtreger, A., Vetter, D. E., & Grando, S. A. (2003). Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis. Life Sciences, 72(18-19), 2063-2067. IF: 2.743 (45/128 – Medicine, Research & Experimental; Q2) Cited 32 times (Cite Score = 2.95 (2016))

Elhasid, R., Sahar, D., Merling, A., Zivony, Y., Rotem, A., Ben-Arush, M., Izraeli, S., Bercovich, D., Larisch, S. (2004). Erratum: Mitochondrial proapoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients (Oncogene (2004), 23). Oncogene, 23(58), 9450. (Cited 2 times). (1-page erratum)

Arredondo, J., Nguyen, V.T., Chernyavsky, A.I., Bercovich, D., Orr-Urtreger, A., Vetter, D.E., Grando, S.A. (2004). Erratum: Functional role of α7 nicotinic receptor in physiological control of cutaneous homeostasis (Life Science, 72 (2063-2067). Life Sciences, 75(9), 1147-1148. (1-page erratum)

Tamary, H., Dgany, O., Toledano, H., Shalev, Z., Krasnov, T., Shalmon, L., Schechter, T., Bercovich, D., Attias, D., Laor, R., Koren, A., & Yaniv, I. (2004). Molecular characterization of three novel Fanconi anemia mutations in Israeli Arabs. European Journal of Haematology72(5), 330-335. IF: 2.378 (33/70 – Hematology; Q2) Cited 13 times (Cite Score = 2.14 (2016))

Hasin, Y., Avidan, N., Bercovich, D., Korczyn, A., Silman, I., Beckmann, J. S., & Sussman, J. L. (2004). A paradigm for single nucle otide polymorphism analysis: The case of the acetylcholinesterase gene. Human Mutation24, 408-416. IF: 4.809 (29/166 – Genetics & Heredity; Q1) Cited 17 times (Cite Score = 4.51 (2016))

Elhasid, R., Sahar, D., Merling, A., Zivony, Y., Rotem, A., Ben-Arush, M., Bercovich, D., & & Larisch, S. (2004). The pro-apoptotic ARTS protein functions as a tumor suppressor in childhood leukemia. Oncogene23(32), 5468-5475. IF: 7.272 (26/286 – Biochemistry & Molecular Biology; Q1) Cited 46 times (Cite Score = 6.59 (2016))

Jiang, Y. H., Sahoo, T., Michaelis, R. C., Bercovich, D., Bressler, J., Kashork, C. D., Liu, Q., Shaffer, L. G., Schroer, R. J., Stockton, D. W., Spielman, R. S., Stevenson, R. E., & Beaudet, A. L. (2004). A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. American Journal of Medical Genetics, 131(1), 1-10. IF: 2.192 (96/166 - Genetics & Heredity; Q3) Cited 96 times (Cite Score = 1.84 (2016))

Nguyen, V. T., Chernyavsky, A. I., Arredondo, J., Bercovich, D., Orr-Urtreger, A., Vetter, D. E., Wess, J., Beaudet, A. L., Kitajima, Y., & Grando, A. S. (2004). Synergistic control of keratinocyte adhesion through muscarinic and nicotinic subtypes of cholinergic receptors. Experimental Cell Research294, 534-549. IF: 3.337 (85/189 – Cell Biology; or 83/217 – Oncology; Q2) Cited 50 times (Cite Score = 3.44 (2016))

  • Liang, Y., Salas, R., Marubio, L., Bercovich, D., De Biasi, M., Beaudet, A. L., & Dani, J. A. (2005). Functional polymorphisms in the human b4 subunit of nicotinic acetylcholine receptors. Neurogenetics6(1), 37-44. IF: 2.851 (63/166 – Genetics & Heredity; Q2) Cited 14 times (Cite Score = 2.94 (2016))

 

Hasin, Y., Avidan, N., Bercovich, D., Korczyn, A. D., Silman, I., Beckmann, J. S., & Sussman J. L. (2005). Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. Current Alzheimer Research, 2(2), 207-218. IF: 3.459 (74/194 – Clinical Neurology; Q2) Cited 8 times (Cite Score = 3.2 (2016))

Basel-Vanagaite, L., Attia, R., Yahav, M., Ferland, R. J., Anteki, L., Walsh, C. A., Olender, T., Straussberg, R., Magal, N., Taub, E., Drasinover, V., Alkelai, A., Bercovich, D., Rechavi, G., Simon, A. J., & Shohat, M. (2005). The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive nonsyndromic mental retardation. Journal of Medical Genetics, 43(3), 203-210. IF: 5.63 (20/166 – Genetics & Heredity; Q1) Cited 83 times (Cite Score = 5.05 (2016))

Sprecher, E., Ishida-Yamamoto, A., Mizrahi-Koren, M., Rapaport, D., Goldsher, D., Indelman, M., Topaz, O., Chefetz, I., Keren, H., O'brien T. J., Bercovich, D., Shalev, S., Geiger, D., Bergman, R., Horowitz, M., & Mandel, H. (2005). A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma. American Journal of Human Genetics, 77(2), 242-251. IF: 10.362 (8/166 – Genetics & Heredity; Q1) Cited 94 times (Cite Score = 8.43 (2016))

Bercovich, D., Friedlander, Y., Korem, S., Hoffman, A., Kleinberg, L., Shochat, C., Leitersdorf, E., & Meiner, V. (2006). The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to Fluvastatin in familial hypercholesterolemia. Atherosclerosis, 185(1), 97-107. IF: 4.086 (37/126 – Cardiac & Cardiovascular Systems or 10/63 – Peripheral Vascular Disease; Q2) Cited 35 times (Cite Score = 3.81 (2016))

Orr-Urtreger, A., Bar-Shira, A., Bercovich, D., Matarasso, N., Rozovsky, U., Rosner, S., Soloviov, S., Rennert, G., Kadouri, L., Hubert, A., Rennert, H., & Matzkin, H. (2006). RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients. Cancer Epidemiology, Biomarkers & Prevention, 15(3), 474-479 IF: 4.202 (63/217 – Oncology or 19/176 - Public, Environmental & Occupational Health; Q2) Cited 18 times (Cite Score = 3.95 (2016))

Bar-Shira, A., Matarasso, N., Rosner, S., Bercovich, D., Matzkin, H., & Orr-Urtreger, A. (2006). Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6. Prostate66(10), 1052-1060. IF: 3.426 (12/76 – Urology & Nephrology; 40/138 – Endocrinology & Metabolism; Q2) Cited 19 times (Cite Score = 3.83 (2016))

Topaz, O., Indelman, M., Chefetz, I., Geiger, D., Metzker, A., Altschuler, Y., Choder, M., Bercovich, D., Uitto, J., Bergman, R., Richard, G., & Sprecher, E. (2006). A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis. American Journal of Human Genetics79(4), 759-764. IF: 10.362 (8/166 – Genetics & Heredity; Q1) Cited 66 times (Cite Score = 8.43 (2016))

Lugassy, J., Itin, P., Ishida-Yamamoto, A., Holland, K., Huson, S., Geiger, D., Hennies, H. C., Indelman, M., Bercovich, D., Uitto, J., Bergman, R., McGrath, J. A., Richard, G., & Sprecher, E. (2006). Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis: two allelic ectodermal dysplasias caused by dominant mutations in KRT14. American Journal of Human Genetics79(4), 724-730. IF: 10.362 (8/166 – Genetics & Heredity; Q1) Cited 65 times (Cite Score = 8.43 (2016))

Feldmesser, E, Bercovich, D., Avidan, N, Halbertal, S, Haim, L, Gross-Isseroff, R, Goshen, S., & Lancet D. (2007). Mutations in olfactory signal transduction genes are not a major cause of human congenital general anosmia. Chemical Senses32(1), 21-30. IF: 2.917 (29/129 – Food Science; or 22/51 – Behavioral Science; Q2) Cited 16 times (Cite Score = 2.48 (2016))

Kadouri, L., Bercovich, D., Elimelech, A., Lerer, I., Sagi, M., Glusman, G., Shochat, C., Korem, S., Hamburger, T., Nissan, A., Abu-Halaf, N., Badryyah, M., Abeliovich, D., & Peretz, T. (2007). A novel BRCA-1 mutation in Arab kindred from east Jerusalem with breast and ovarian cancer. BMC Cancer, 7(1), 7-14. IF: 3.645 (93/217 – Oncology; Q2) Cited 14 times (Cite Score = 3.56 (2016))

Goldberg, Y., Porat, R., Sagi, M., Eilat, A., Kedar, I., Shochat, C., Mendelson, S., Hamburger, T., Nissan, A., Hubert, A., Shalev, S., Bercovich, D., Pikarski, E., Lerer, I., Abeliovich, D., & Pretetz, T. (2007). A new oncogenetic service of counseling and diagnosing for hereditary non-polyposis colorectal cancer (HNPCC). Harefuah, 146(7), 510-514. IF: 0.15 (On Rank) Cited 1 time (Cite Score = 0.13 (2016))

Orr-Urtreger, A., Shifrin, C., Rozovski, U., Rosner, S., Bercovich, D., Gurevich, T., Yagev-More, H., Bar-Shira, A., & Giladi, N. (2007). The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinson disease: Is there a gender effect? Neurology, 69(16), 1595-1602. IF: 8.156 (10/194 – Clinical Neurology; Q1) Cited 87 times (Cite Score = 3.81 (2016))

Kadouri, I., Bercovich, D., Rottenberg, Y., Korem, S., Elimelech, A., Uziely, B., Safra, T., Ron, I. G., Peretz, T., & Yaal-Hahoshen, N. (2008). Effect of single-nucleotide polymorphisms in the CYP19 gene on response to Letrozole among breast cancer patients. Journal of Clinical Oncology, 26(15), 22096. (1-page publication)

Goodman, G., & Bercovich, D. (2008). Prolactin does not cause breast cancer and may prevent it or be therapeutic in some conditions. Medical Hypotheses, 70(2), 244-25. IF: 1.113 (105/128 – Medicine, Research & Experimental; Q4) Cited 17 times (Cite Score = 1.13 (2016))

Lugassy, J., McGrath, J.A., Itin, P., Shemer, R., Verbov, J., Murphy, H.R., Ishida-Yamamoto, A., Digiovanna, J.J., Bercovich, D., Karin, N., Vitenshtein, A., Uitto, J., Bergman, R., Richard, G., & Sprecher, E. (2008). KRT14 haploinsufficiency results in increased susceptibility of Keratinocytes to TNF-alpha-induced apoptosis and causes Naegeli-Franceschetti-Jadassohn syndrome. Journal of Investigative Dermatology128(6), 1517-1524. IF: 6.643 (2/63 – Dermatology; Q1) Cited 28 times (Cite Score = 3.8 (2016))

Bercovich, D., Elimelech, A., Yardeni, T., Korem, S., Zlotogora, J., Gal, N., Goldstein, N., Vilensky, B., Segev, R., Avraham, S., Loewenthal, R., Schwartz, G., & Anikster, Y. (2008). A mutation analysis of the Phenylalanine Hydroxylase (PAH) gene in the Israeli population. Annals of Human Genetics72(Pt 3), 305-309. IF: 1.722 (121/166 – Genetics & Heredity; Q3) Cited 14 times (Cite Score = 1.65 (2016))

Bercovich, D., Elimelech, A., Zlotogora, J., Korem, S., Yardeni, T., Gal, N., Goldstein, N., Vilensky, B., Segev, R., Avraham, S., Loewenthal, R., Schwartz, G., & Anikster Y. (2008). Genotype–phenotype correlations analysis of mutations in the phenylalanine hydroxylase (PAH) gene. Journal of Human Genetics53(5), 407-418. IF: 2.358 (85/166 – Genetics & Heredity; Q3) Cited 23 times (Cite Score = 2.18 (2016))

Hershkovitz, D, Bercovich, D., Sprecher, E., & Lapidot, M. (2008). RASA1 mutations may cause hereditary capillary malformations without arteriovenous malformations. British Journal of Dermatology, 158(5), 1035-1040. IF: 4.824 (5/63 – Dermatology; Q1) Cited 48 times (Cite Score = 2.59 (2016))

Goldberg, Y., Porat, R. M., Kedar, I., Shochat, C., Sagi, M., Eilat, A., Mendelson, S., Hamburger, T., Nissan, A., Hubert, A., Kadouri, L., Pikarski, E., Lerer, I., Abeliovich, D., Bercovich, D., & Peretz T. (2008). Mutation spectrum in HNPCC in the Israeli population. Familial Cancer7(4), 309-17. IF: 1.905 (177/217 – Oncology; Q4) Cited 13 times (Cite Score = 2.07 (2016))

Goodman, G., & Bercovich, D. (2008). Melanin directly converts light for vertebrate metabolic use: heuristic thoughts on birds, Icarus and dark human skin. Medical Hypotheses71(2), 190-202. IF: 1.113 (105/128 – Medicine, Research & Experimental; Q4) Cited 9 times (Cite Score = 1.13 (2016))

Bercovich, D., Ganmore, I., Scott, L.M., Weinreb, G., Elimelech, A., Cazzaniga, G., Biondi, A., Basso, G., Cario, G., Schrappe, M., Stanulla, M., Strehl, S., Haas, O.A., Mann, G., Binder, V., Borkhardt, A., Kempski, H., Trka, J., Bielorei, B., Avigad, S., Stark, B., Smith, O., Dastugue, N., Bourquin, J. P., Ben Tal, N., Green, A. R., & Izraeli, S. (2008). Unique activating mutations of JAK2 in the acute lymphoblastic leukemias of Down Syndrome (DS). Lancet, 25; 372(9648), 1484-1492. IF: 48.082 (2/154 – Medicine, General & Internal.; Q1) Cited 214 times (Cite Score = 6.63 (2016))

Toledano, H., Goldberg, Y., Kedar-Barnes, I., Baris, H., Porat, R. M., Shochat, C., Bercovich, D., Pikarsky, E., Lerer, I., Yaniv, I., Abeliovich, D., & Peretz, T. (2008). Homozygosity of MSH2 c.1906G-->C germline mutation is associated with childhood colon cancer, astrocytoma and signs of Neurofibromatosis Type I. Familial Cancer8(3), 187-194. IF: 1.905 (177/217 – Oncology; Q4) Cited 14 times (Cite Score = 2.07 (2016))

Bercovich, D., & Goodman, G. (2009). Pregnancy and lactation after Breast Cancer elevate plasma Prolactin, do not shorten and may prolong survival. Medical Hypotheses73(6), 942-947. IF: 1.113 (105/128 – Medicine, Research & Experimental; Q4) Cited 5 times (Cite Score = 1.13 (2016))

Half, E, Bercovich, D., & Rozen, P. (2009). Familial adenomatous polyposis. Orphanet Journal of Rare Diseases, 12(4), 22. IF: 4.191 (58/166 – Genetics & Heredity or 35/128 – Medicine, Research; Q2) Cited 189 times (Cite Score = 3.31 (2016))

Raz, A., Stern, R. A., Bercovich, D., & Goldway, M. (2009). SFB-based S-haplotyping of apricot (Prunus armeniaca) with DHPLC. Plant Breeding128(6), 707-711. IF: 1.595 (29/83 – Agronomy or 106/211 – Plant Sciences; Q2) Cited 6 times (Cite Score = 1.75 (2016))

Hertzberg, L., Vendramini, E., Ganmore, I., Cazzaniga, G., Schmitz, M., Chalker, J., Shiloh, R., Iacobucci, I., Shochat, C., Zeligson, S., Cario, G., Stanulla, M., Strehl, S., Russell, S. J., Harrison, C. J., Bornhauser, B., Yoda, A., Rechavi, G., Bercovich, D., Borkhardt, A., Kempski, H., Kronnie, G., Bourquin, J. P., Domany, E., & Izraeli, S. (2010). Down syndrome acute ymphoblastic leukemia: a highly heterogeneodisease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the iBFM Study Group. Blood115(5), 1006-1017. IF: 10.891 (2/70 – Hematology; Q1) Cited 185 times (Cite Score = 6.93 (2016))

* Levy-Litan, V., Hershkovitz, E., Avizov, L., Leventhal, N., Bercovich, D., Chalifa-Caspi, V., Manor, E., Buriakovsky, S., Hadad, Y., Goding J., & Parvari, R. (2010). Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene. American Journal of Human Genetics86(2), 273-8. IF: 10.362 (8/166 – Genetics & Heredity; Q1) Cited 123 times (Cite Score = 8.43 (2016))

* Shapiro, R, Anikster, Y, Yardeni, T, Korem, S, Hartman, K, Shamir, R, Broide, E, Levine, A, Bujanover, Y., & Bercovich, D. (2010). DHPLC screening for mutations in progressive familial intrahepatic cholestasis patients. Journal of Human Genetics, Apr 23, 308-313. IF: 2.358 (85/166 – Genetics & Heredity; Q3) Cited 5 times (Cite Score = 2.18 (2016))

* Goldberg, Y., Porat, R., Kedar, I., Shochat, C., Galinsky, D., Hamburger, T., Hubert, A., Strul, H., Kariiv, R., Ben-Avi, L., Savion, M., Pikarsky, E., Abeliovich, D., Bercovich, D., Lerer, I., & Peretz, T. (2010). An Ashkenazi founder mutation in the MSH6 gene leading to HNPCC. Familial Cancer, 9(2), 141-50. IF: 1.905 (177/217 – Oncology; Q4) Cited 10 times (Cite Score = 2.07 (2016))

* Rosner, G., Paul, R., Bercovich, D., Shochat, C., Solar, I., Strul, H., Kariv, R., & Halpern Z. (2010). A protocol for genetic evaluation of patients with multiple colorectal adenomas and without evidence of APC gene mutation. Israel Medical Association Journal, 12(9), 549-53 IF: 1.040 (98/154 – Medicine, General & Internal.; Q3) Cited 5 times (Cite Score = 0.81 (2016))

* Shochat, C., Tal, N., Bandapalli, O.R., Palmi, C., Ganmore, I., te Kronnie, G., Cario, G., Cazzaniga, G., Kulozik, A.E., Stanulla, M., Schrappe, M., Biondi, A., Basso, G., Bercovich, D., Muckenthaler, M.U., & Izraeli, S. (2011). Gain-of-function mutations in nterleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias. Journal of Experimental Medicine, 208(6), 1333. (1-page publication)

* Sagi, M., Eilat, A., Ben Avi, L., Goldberg, Y., Bercovich, D., Hamburger, T., Peretz, T., & Lerer, I. (2011). Two BRCA1/2 founder mutations in Jews of Sephardic origin. Familial Cancer, 10(1), 59-63. IF: 1.905 (177/217 – Oncology; Q4) Cited 8 times (Cite Score = 2.07 (2016))

* Geyer, O, Wolf, A, Levinger, E, Harari-Shacham, A, Walton, DS, Shochat, C, Korem, S., & Bercovich, D. (2011). Genotype/phenotype correlation in primary congenital glaucoma patients from different ethnic groups of the Israeli population. American Journal of Ophthalmology, 151(2), 263-271. IF: 4.979 (4/59 – Ophthalmology; Q1) Cited 12 times (Cite Score = 3.8 (2016))

* Shochat, C., Tal, N., Bandapalli, O. R., Palmi, C., Ganmore, I., Kronnie, G.T., Cario, G., Cazzaniga, G., Kulozik, A. E., Stanulla, M., Schrappe, M., Biondi, A., Basso, G., Bercovich, D., Muckenthaler, M. U., & Izraeli, S. (2011). Gain-of-function mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias. Journal of Experimental Medicine208(5), 901-8. IF:13.285 (7/150 – Immunology; or 5/128 – Medicine, Research & Exprimental; Q1) Cited 141 times (Cite Score = 10.19 (2016))

* Mandel, H., Bali, D., Kishnani, P. S., Bar-Joseph, G., Lorber, A., Khoury, A., Natan, D., Eldad, D. J., Zeigler, M., Bercovich, D., Plotkin, H., & Herskovitz, E. (2012). Outcome of pompe disease infants with negative cross-reactive immunologic material from Israel and Gaza. Clinical Therapeutics, 33(6), S17. (1-page publication)

* Shlush, L. I., Chapal-Ilani, N., Adar, R., Pery, N., Maruvka, Y., Spiro, Adam, S., Rowe, R., Jacob, M., Tzukerman, M., Bercovich, D., Izraeli, S., Marcucci, G., Bloomfield, C. D., Zuckerman, T., Skorecki, K., & Shapiro, E. (2012). Cell lineage analysis of acute leukemia relapse uncovers the role of replication-rate heterogeneity and miscrosatellite instability. Blood, 120(3), 603-12. IF: 10.891 (2/70 – Hematology; Q1) Cited 38 times (Cite Score = 6.93 (2016))

* Goodman, G., Gershwin, M. E., & Bercovich, D. (2012). Fullerene and the origin of life. Israel Medical Association Journal14(10), 602-6. IF: 1.040 (98/154 – Medicine, General & Internal.; Q3) Cited 6 times (Cite Score = 0.81 (2016))

* Bercovich, D., Korem, S, Snauder, L., & Degani, G. (2012). Genetic diversity of color phenotypes in the koi (Cyprinus carpio L) as identified by molecular markers. Journal of Biophysical Chemistry, 3(3), 249-255. IF: 2.121(169/286 – Biochemistry & Molecular Biology; Q3) Cited 0 times (Cite Score = 0.63 (2016))

* Goodman, G., & Bercovich, D. (2013). Electromagnetic induction between axons and their schwann cell myelin-protein sheaths. Journal of Integrative Neuroscience. Dec; 12(4), 475-89. IF: 0.791(245/258 – Neurosciences; Q4) Cited 4 times (Cite Score = 0.7 (2016))

* Tzadok, M., Nissenkorn, A., Porper, K., Matot, I., Marcu, S., Anikster, Y., Menascu, S., Bercovich, D., & Zeev, B. B. (2014). The many faces of Glut1 Deficiency SyndromeJournal of Child Neurology, 71(3), 365-78. IF: 1.536 (155/194 – Clinical Neurology or 74/121 – Pediatrics; Q4) Cited 10 times (Cite Score = 1.44 (2016))

* Tal, N., Shochat, C., Geron, I., Bercovich, D., & Izraeli, S. (2014). Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia. Cellular and Molecular Life Sciences71(3), 365-78. IF: 5.643 (40/286 – Biochemistry & Molecular Biology or 41/189 – Cell Biology; Q1) Cited 18 times (Cite Score = 5.62 (2016))

* Shochat, C., Tal, N., Gryshkova, V., Birger, Y., Bandapalli, O. R., Cazzaniga, G., Gershman, N., Kulozik, A. E., Biondi, A., Mansour, M. R., Twizere, J.-C., Muckenthaler, M. U., Ben-Tal, N., Constantinescu, S. N., Bercovich, D., & Izraeli, S. (2014). Novel activating mutations lacking cysteine in type I cytokine receptors in acutelymphoblastic leukemia. Blood124(1), 106-10. IF: 10.891 (2/70 – Hematology; Q1) Cited 17 times (Cite Score = 6.93 (2016))

* Goodman, G., Gershwin, M. E., & Bercovich, D. (2014). Mars can wait: Facing the challenges of our civilization. Israel Medical Association Journal16(12), 744-7. IF: 1.040 (98/154 – Medicine, General & Internal.; Q3) Cited: 7 (Cite Score = 0.81 (2016))

* Tenenbaum-Rakover, Y., Almashanu, S., Hess, O., Admoni, O., Hag-Dahood Mahameed, A., Schwartz, A., Allon-Shalev, S., Bercovich, D., Refetoff, S. (2015). Erratum: Long-Term outcome of loss-of-function mutations in thyrotropin receptor gene (Thyroid, 25(3), 292-299). Thyroid, 25(8), 977. (1-page erratum)

* Dekel, Y., Machluf, Y., Ben-Dor, S., Yifa, O., Stoler, A., Ben-Shlomo, I., & Bercovich, D. (2015). Dispersal of an ancient retroposon in the TP53 promoter of Bovidae: phylogeny, novel mechanisms, and potential implications for Cow milk persistency. BMC Genomics16(1), 53. IF: 4.284 (50/166 – Genetics & Heredity or 33/158 – Biotechnology & Applied Microbiology; Q1) Cited: 1 (Cite Score = 4.05 (2016))

* Tenenbaum-Rakover, Y., Almashanu, S., Hess, O., Admoni, O., Hag-Dahood Mahameed, A., Schwartz, N., Bercovich, D. & Refetoff, S. (2015). Long-term outcome of children with TSH receptor gene mutations. Thyroid, 25(3), 292-9. IF: 5.068 (18/138 – Endocrinology & Metabolism; Q1) Cited: 5 (Cite Score = 4.06 (2016))

* Rozner, G., BercovichD., Daniel, Y. E., Pel, S., Samuel, Z., Strul, H., Santo, E., Halpern, Z., & Kariv R. (2015). Increased risk for colorectal adenomas and cancer in mono-allelic MUTYH mutation carriers: results from a cohort of North-African Jews. Familial Cancer14(3), 427-36. IF: 1.905 (177/217 – Oncology; Q4) Cited: 0 (Cite Score = 2.07 (2016))

* Tenenbaum-Rakover, Y., Weinberg-Shukron, A., Renbaum, P., Levy-Lahad, E., Bercovich D., & Zangen, D. (2015). Minichromosome maintenance complex component 8 (MCM8) gene mutation result in primary gonadal failure. Journal of Medical Genetics, 52(6), 391-9. IF: 5.630 (20/166 – Genetics & Heredity; Q1) Cited: 15 (Cite Score = 5.05 (2016))

* Goodman, G., Poznanski, R. R., Cacha, L., & Bercovich, D. (2015). The Two-Brain hypothesis: Towards a guide for brain–brain and brain–machine interfaces. Journal of Integrative Neuroscience14(3), 281-93. IF: 0.791(245/258 – Neurosciences; Q4) Cited: 1 (Cite Score = 0.70 (2016))

* Baris, H. N., Barnes-Kedar, I., Toledano, H., Halpern, M., Lossos, Al., Lerer, I., Peretz, T., Kariv, R., Cohen, S., Half, E. E., Magal, N., Drasinover, V., Wimmer, K., Goldberg, Y., Bercovich, D., & Levi Z. (2016). Constitutional mismatch repair deficiency caused by founder mutations in MMR genes in Israel. Pediatric Blood & Cancer63(3), 418-27. IF: 2.632 (133/217 – Oncology or 36/70 – Hematology; Q3) Cited: 3 (Cite Score = 2.26 (2016))

Bercovich, D., Shlush, K., & Goodman, G. (2016). Case study: A human pre-atal experiment in 1944 - 'Do no harm.' Open Journal of Obstetrics and Gynecology6, 49-156. IF: 0.51(On Rank)) Cited: 0

BercovichD., Goodman, G., & Gershwin, M. E. (2016). A myriad of planets and birds: Drake's universe, down to earth and the search for extraterrestrial life. Israel Medical Association Journal18(8), 445-448. IF: 1.040 (98/154 – Medicine, General & Internal.; Q3) Cited: 0 (Cite Score = 0.81 (2016))

* Tenenbaum-Rakover, Y., Turgeon, M.-O., London, S., Hermanns, P., Pohlenz, J., Bernard, D. J., & Bercovich, D. (2016). Familial central hypothyroidism caused by a novel IGSF1 gene mutation. Thyroid26(12), 1693-1700. IF: 5.068 (18/138 – Endocrinology & Metabolism; Q1) Cited: 5 (Cite Score = 4.06 (2016))

* Spiegel, R., Shalev, S., BercovichD., Rabinovich, D., Shaag, A., Khayat, M., & Elpeleg, O. (2016). Severe infantile male encephalopathy is a result of early post-zygotic WDR45 somatic mutation. Clinical Genetics90(6), 560-562. IF: 3.350 (62/166 (Genetics & Heredity; Q2) Cited: 0 (Cite Score = 8.56 (2016)

* Dekel, Y., Machluf, Y., Brand, R., Partouche, O. N., Ben-Shlomo, I., & Bercovich, D. (2017). Mammal domestication and the symbiotic spectrum (Letter to the Editor). Proceedings of the National Academy of Sciences of the United States of America, 114(27). IF: 10.414 (4/64 – Multidisciplinary Sciences; Q1) Cited: 1 (Cite Score = 8.56 (2016).

* Solomon-Zemler, R., Basel-Vanagaite, L., Steier, D., Yakar, S., Mel, E., Phillip, M., Bazak, L., Bercovich, D., Werner, H., & de Vries, L. (2017). A novel heterozygous igf-1 receptor mutation associated with hypoglycemia. Endocrine Connections, 6(6), 395-403. IF: 2.387 (83/138 – Endocrinology & Metabolism; Q3) Cited: 0

* Dekel, Y., Machluf, Y., Stoler, A., Aderet, A., Baumel, D., Plotsky, Y., Partouche, O. N., Ben-Shlomo, I., & BercovichD. (2017). Frequency of the canine nt230(del4) MDR1 allele in Israel. BMC Veterinary Research, Nov 13;13(1):333. IF: 1.75 (24/136 – Veterinary Sciences; Q1) Cited: 0 (Cite Score = 2.43 (2016))

* Degani, G., Alon, A., Dekela, Y., Stoler. A., & Bercovich, D. (2017). Evidence of a reproduction-related function for brine Kisspeptin 2 and its receptors in an Anabantidae fish (Trichogaster trichopterus(. International Journal of Zoological Investigations, 3(2), 106-122. IF (IIJIF): 2.41(135/163 – Endocrinology & Metabolism; Q4) Cited: 0.

* Berkovitz, A., Dekel, Y., Goldstein, R., Bsoul, S., Machluf, Y., & Bercovich, D. (2018). The significance of spermatozoa vacuoles can be resolved by a novel procedure of array comparative genomic hybridization. Human Reproduction, Feb 6, 1–9. IF: 5.02 (2/29 – Reproductive Biology; Q1) Cited: 0 (Cite Score = 1.13 (2016)).

* Rosner, G., Gluck, N., Carmi, S., Bercovich, D., Fliss-Issakov, N., Ben-Yehoyada, M., Aharon-Caspi, S., Kellerman, E., Strul, H., Shibolet, O., & Kariv, R. (2018). POLD1 and POLE gene mutations in Jewish cohorts of early-onset colorectal cancer and of multiple colorectal adenomas. Diseases of the Colon & Rectum, 61(9), 1073-1079. IF: 3.616 (26/80 – Gastroenterology & Hepatology; Q2) Cited: 0 (Cite Score = 1.045 (2017))

* Geyer, O, Wolf, A, Levinger, E, Harari-Shacham, A, Walton, DS, Shochat, C, Korem, S., & Bercovich, D. (2011). Genotype/phenotype correlation in primary congenital glaucoma patients from different ethnic groups of the Israeli population. American Journal of Ophthalmology, 151(2), 263-271. IF: 4.979 (4/59 – Ophthalmology; Q1) Cited 12 times (Cite Score = 3.8 (2016))

* Shochat, C., Tal, N., Bandapalli, O. R., Palmi, C., Ganmore, I., Kronnie, G.T., Cario, G., Cazzaniga, G., Kulozik, A. E., Stanulla, M., Schrappe, M., Biondi, A., Basso, G., Bercovich, D., Muckenthaler, M. U., & Izraeli, S. (2011). Gain-of-function mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias. Journal of Experimental Medicine208(5), 901-8. IF:13.285 (7/150 – Immunology; or 5/128 – Medicine, Research & Exprimental; Q1) Cited 141 times (Cite Score = 10.19 (2016))

* Mandel, H., Bali, D., Kishnani, P. S., Bar-Joseph, G., Lorber, A., Khoury, A., Natan, D., Eldad, D. J., Zeigler, M., Bercovich, D., Plotkin, H., & Herskovitz, E. (2012). Outcome of pompe disease infants with negative cross-reactive immunologic material from Israel and Gaza. Clinical Therapeutics, 33(6), S17. (1-page publication)

* Shlush, L. I., Chapal-Ilani, N., Adar, R., Pery, N., Maruvka, Y., Spiro, Adam, S., Rowe, R., Jacob, M., Tzukerman, M., Bercovich, D., Izraeli, S., Marcucci, G., Bloomfield, C. D., Zuckerman, T., Skorecki, K., & Shapiro, E. (2012). Cell lineage analysis of acute leukemia relapse uncovers the role of replication-rate heterogeneity and miscrosatellite instability. Blood, 120(3), 603-12. IF: 10.891 (2/70 – Hematology; Q1) Cited 38 times (Cite Score = 6.93 (2016))

* Goodman, G., Gershwin, M. E., & Bercovich, D. (2012). Fullerene and the origin of life. Israel Medical Association Journal14(10), 602-6. IF: 1.040 (98/154 – Medicine, General & Internal.; Q3) Cited 6 times (Cite Score = 0.81 (2016))

* Bercovich, D., Korem, S, Snauder, L., & Degani, G. (2012). Genetic diversity of color phenotypes in the koi (Cyprinus carpio L) as identified by molecular markers. Journal of Biophysical Chemistry, 3(3), 249-255. IF: 2.121(169/286 – Biochemistry & Molecular Biology; Q3) Cited 0 times (Cite Score = 0.63 (2016))

* Goodman, G., & Bercovich, D. (2013). Electromagnetic induction between axons and their schwann cell myelin-protein sheaths. Journal of Integrative Neuroscience. Dec; 12(4), 475-89. IF: 0.791(245/258 – Neurosciences; Q4) Cited 4 times (Cite Score = 0.7 (2016))

* Tzadok, M., Nissenkorn, A., Porper, K., Matot, I., Marcu, S., Anikster, Y., Menascu, S., Bercovich, D., & Zeev, B. B. (2014). The many faces of Glut1 Deficiency SyndromeJournal of Child Neurology, 71(3), 365-78. IF: 1.536 (155/194 – Clinical Neurology or 74/121 – Pediatrics; Q4) Cited 10 times (Cite Score = 1.44 (2016))

* Tal, N., Shochat, C., Geron, I., Bercovich, D., & Izraeli, S. (2014). Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia. Cellular and Molecular Life Sciences71(3), 365-78. IF: 5.643 (40/286 – Biochemistry & Molecular Biology or 41/189 – Cell Biology; Q1) Cited 18 times (Cite Score = 5.62 (2016))

* Shochat, C., Tal, N., Gryshkova, V., Birger, Y., Bandapalli, O. R., Cazzaniga, G., Gershman, N., Kulozik, A. E., Biondi, A., Mansour, M. R., Twizere, J.-C., Muckenthaler, M. U., Ben-Tal, N., Constantinescu, S. N., Bercovich, D., & Izraeli, S. (2014). Novel activating mutations lacking cysteine in type I cytokine receptors in acutelymphoblastic leukemia. Blood124(1), 106-10. IF: 10.891 (2/70 – Hematology; Q1) Cited 17 times (Cite Score = 6.93 (2016))

* Goodman, G., Gershwin, M. E., & Bercovich, D. (2014). Mars can wait: Facing the challenges of our civilization. Israel Medical Association Journal16(12), 744-7. IF: 1.040 (98/154 – Medicine, General & Internal.; Q3) Cited: 7 (Cite Score = 0.81 (2016))

* Tenenbaum-Rakover, Y., Almashanu, S., Hess, O., Admoni, O., Hag-Dahood Mahameed, A., Schwartz, A., Allon-Shalev, S., Bercovich, D., Refetoff, S. (2015). Erratum: Long-Term outcome of loss-of-function mutations in thyrotropin receptor gene (Thyroid, 25(3), 292-299). Thyroid, 25(8), 977. (1-page erratum)

* Dekel, Y., Machluf, Y., Ben-Dor, S., Yifa, O., Stoler, A., Ben-Shlomo, I., & Bercovich, D. (2015). Dispersal of an ancient retroposon in the TP53 promoter of Bovidae: phylogeny, novel mechanisms, and potential implications for Cow milk persistency. BMC Genomics16(1), 53. IF: 4.284 (50/166 – Genetics & Heredity or 33/158 – Biotechnology & Applied Microbiology; Q1) Cited: 1 (Cite Score = 4.05 (2016))

* Tenenbaum-Rakover, Y., Almashanu, S., Hess, O., Admoni, O., Hag-Dahood Mahameed, A., Schwartz, N., Bercovich, D. & Refetoff, S. (2015). Long-term outcome of children with TSH receptor gene mutations. Thyroid, 25(3), 292-9. IF: 5.068 (18/138 – Endocrinology & Metabolism; Q1) Cited: 5 (Cite Score = 4.06 (2016))

* Rozner, G., BercovichD., Daniel, Y. E., Pel, S., Samuel, Z., Strul, H., Santo, E., Halpern, Z., & Kariv R. (2015). Increased risk for colorectal adenomas and cancer in mono-allelic MUTYH mutation carriers: results from a cohort of North-African Jews. Familial Cancer14(3), 427-36. IF: 1.905 (177/217 – Oncology; Q4) Cited: 0 (Cite Score = 2.07 (2016))

* Tenenbaum-Rakover, Y., Weinberg-Shukron, A., Renbaum, P., Levy-Lahad, E., Bercovich D., & Zangen, D. (2015). Minichromosome maintenance complex component 8 (MCM8) gene mutation result in primary gonadal failure. Journal of Medical Genetics, 52(6), 391-9. IF: 5.630 (20/166 – Genetics & Heredity; Q1) Cited: 15 (Cite Score = 5.05 (2016))

* Goodman, G., Poznanski, R. R., Cacha, L., & Bercovich, D. (2015). The Two-Brain hypothesis: Towards a guide for brain–brain and brain–machine interfaces. Journal of Integrative Neuroscience14(3), 281-93. IF: 0.791(245/258 – Neurosciences; Q4) Cited: 1 (Cite Score = 0.70 (2016))

* Baris, H. N., Barnes-Kedar, I., Toledano, H., Halpern, M., Lossos, Al., Lerer, I., Peretz, T., Kariv, R., Cohen, S., Half, E. E., Magal, N., Drasinover, V., Wimmer, K., Goldberg, Y., Bercovich, D., & Levi Z. (2016). Constitutional mismatch repair deficiency caused by founder mutations in MMR genes in Israel. Pediatric Blood & Cancer63(3), 418-27. IF: 2.632 (133/217 – Oncology or 36/70 – Hematology; Q3) Cited: 3 (Cite Score = 2.26 (2016))

Bercovich, D., Shlush, K., & Goodman, G. (2016). Case study: A human pre-atal experiment in 1944 - 'Do no harm.' Open Journal of Obstetrics and Gynecology6, 49-156. IF: 0.51(On Rank)) Cited: 0

BercovichD., Goodman, G., & Gershwin, M. E. (2016). A myriad of planets and birds: Drake's universe, down to earth and the search for extraterrestrial life. Israel Medical Association Journal18(8), 445-448. IF: 1.040 (98/154 – Medicine, General & Internal.; Q3) Cited: 0 (Cite Score = 0.81 (2016))

* Tenenbaum-Rakover, Y., Turgeon, M.-O., London, S., Hermanns, P., Pohlenz, J., Bernard, D. J., & Bercovich, D. (2016). Familial central hypothyroidism caused by a novel IGSF1 gene mutation. Thyroid26(12), 1693-1700. IF: 5.068 (18/138 – Endocrinology & Metabolism; Q1) Cited: 5 (Cite Score = 4.06 (2016))

* Spiegel, R., Shalev, S., BercovichD., Rabinovich, D., Shaag, A., Khayat, M., & Elpeleg, O. (2016). Severe infantile male encephalopathy is a result of early post-zygotic WDR45 somatic mutation. Clinical Genetics90(6), 560-562. IF: 3.350 (62/166 (Genetics & Heredity; Q2) Cited: 0 (Cite Score = 8.56 (2016)

* Dekel, Y., Machluf, Y., Brand, R., Partouche, O. N., Ben-Shlomo, I., & Bercovich, D. (2017). Mammal domestication and the symbiotic spectrum (Letter to the Editor). Proceedings of the National Academy of Sciences of the United States of America, 114(27). IF: 10.414 (4/64 – Multidisciplinary Sciences; Q1) Cited: 1 (Cite Score = 8.56 (2016).

* Solomon-Zemler, R., Basel-Vanagaite, L., Steier, D., Yakar, S., Mel, E., Phillip, M., Bazak, L., Bercovich, D., Werner, H., & de Vries, L. (2017). A novel heterozygous igf-1 receptor mutation associated with hypoglycemia. Endocrine Connections, 6(6), 395-403. IF: 2.387 (83/138 – Endocrinology & Metabolism; Q3) Cited: 0

* Dekel, Y., Machluf, Y., Stoler, A., Aderet, A., Baumel, D., Plotsky, Y., Partouche, O. N., Ben-Shlomo, I., & BercovichD. (2017). Frequency of the canine nt230(del4) MDR1 allele in Israel. BMC Veterinary Research, Nov 13;13(1):333. IF: 1.75 (24/136 – Veterinary Sciences; Q1) Cited: 0 (Cite Score = 2.43 (2016))

* Degani, G., Alon, A., Dekela, Y., Stoler. A., & Bercovich, D. (2017). Evidence of a reproduction-related function for brine Kisspeptin 2 and its receptors in an Anabantidae fish (Trichogaster trichopterus(. International Journal of Zoological Investigations, 3(2), 106-122. IF (IIJIF): 2.41(135/163 – Endocrinology & Metabolism; Q4) Cited: 0.

* Berkovitz, A., Dekel, Y., Goldstein, R., Bsoul, S., Machluf, Y., & Bercovich, D. (2018). The significance of spermatozoa vacuoles can be resolved by a novel procedure of array comparative genomic hybridization. Human Reproduction, Feb 6, 1–9. IF: 5.02 (2/29 – Reproductive Biology; Q1) Cited: 0 (Cite Score = 1.13 (2016)).

* Rosner, G., Gluck, N., Carmi, S., Bercovich, D., Fliss-Issakov, N., Ben-Yehoyada, M., Aharon-Caspi, S., Kellerman, E., Strul, H., Shibolet, O., & Kariv, R. (2018). POLD1 and POLE gene mutations in Jewish cohorts of early-onset colorectal cancer and of multiple colorectal adenomas. Diseases of the Colon & Rectum, 61(9), 1073-1079. IF: 3.616 (26/80 – Gastroenterology & Hepatology; Q2) Cited: 0 (Cite Score = 1.045 (2017)

Accordion Title Prof. Dani Bercovich CV

Prof. Dani Bercovich CV

Document name: Prof Dani Bercovich CV